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Brain Function Lateralisation May Be Distributed Along Four Functional Axes

Tractography of corpus callosum

The first complete mapping of cerebral functional lateralisation has been reported by a Franco-Italian research team.

Their results show for the very first time that as well as perception, action and emotions, decision-making uses the right half of the brain more. On the other hand, symbolic communication uses the left half of the brain more.

Some cerebral processes preferably occur in the brain’s right or left hemisphere. But the question of which functions and which side has remained unanswered.

Left Or Right Brained?

In 1865, French physician Paul Broca noted that among patients with brain damage, only those with the left frontal lobe affected had speech difficulties. This is the first time that functional asymmetry has been observed between the two hemispheres.

Much research followed to try to identify the “dominant” hemisphere for various brain functions, but without global investigation of lateralisation.

That was until the recent research by Michel Thiebaut de Schotten, a CNRS researcher at the Institut du Cerveau et de la Moelle Epinière (AP-HP/CNRS/INSERM/Sorbonne Université), and his colleagues at the University of Padua, Italy. Using functional MRI data collected worldwide for more than 15 years, they have produced the first global map of cerebral function lateralisation.

Cerebral functional lateralisation
Cerebral functional lateralisation represented in a 4-dimensional space along the symbolic communication axis (green), the perception/action axis (cyan), the emotions axis (pink) and the decision-making axis (yellow).
Credit: Karoliset al./Nature Communications

The researchers have identified four groups of extremely lateralised functions using common cerebral regions: symbolic communication (where we find language, reading and calculation, for example) very much on the left; the perception/action and emotions groups on the right and decision-making, which is in the right frontal lobe area.

The last point is completely innovative. No team had previously described asymmetry between hemispheres for decision-making.

Inter-hemispheric Independence

In addition, this study answered a problematic question on connections between hemispheres: are the very lateralised regions not substantially connected with the other hemisphere so that information is processed faster, or on the contrary are they very connected so that they influence and dominate the opposite hemisphere in some cases?

The researchers’ map shows that the more lateralised the function, the less it establishes connections with the other hemisphere, so validating the hypothesis that to be more efficient, a function’s dominant hemisphere is not highly connected with the other side.

Archetypes of functional lateralisation
Archetypes of functional lateralisation.
Credit: Karoliset al./Nature Communications

This discovery also validates the idea that brain functions became lateralised as the brain got larger, to optimise information processing. This optimisation occurred at the expense of another evolutionary advantage though: functional recovery after brain damage.

Because of reduced connections between hemispheres, it is harder for the undamaged hemisphere to compensate for the lost functions.

The researchers will now continue this work by studying variations in function lateralisation between individuals and testing for example whether high lateralisation for a function in one person causes different lateralisation for other functions.

Vyacheslav R. Karolis, Maurizio Corbetta & Michel Thiebaut de Schotten
The architecture of functional lateralisation and its relationship to callosal connectivity in the human brain
Nature Communications volume 10, Article number: 1417 (2019)

Top Image: Vyacheslav R. Karolis et al. CC-BY