Medical consensus once supported daily use of low dose aspirin to prevent heart attack and stroke in people at increased risk for cardiovascular disease (CVD). But in 2018, three major clinical trials cast doubt on that conventional wisdom, finding few benefits and consistent bleeding risks associated with daily aspirin use.
Taken together, the findings led the American Heart Association and American College of Cardiology to change clinical practice guidelines earlier this year, recommending against the routine use of aspirin in people older than 70 years or people with increased bleeding risk who do not have existing cardiovascular disease.
“Although prior American Heart Association and American College of Cardiology guidelines recommended aspirin only in persons without elevated bleeding risk, the 2019 guidelines now explicitly recommend against aspirin use among those over the age of 70 who do not have existing heart disease or stroke. Our findings suggest that a substantial portion of adults may be taking aspirin without their physician’s advice and potentially without their knowledge."
said senior author Christina C. Wee, MD, MPH, a general internist and researcher at BIDMC and Associate Professor of Medicine at Harvard Medical School.
Daily Aspirin Use
Aspirin use is widespread among groups at risk for harm including older adults and adults with peptic ulcers - painful sores in the lining of the stomach that are prone to bleeding that affect about one in ten people.
Using data from the 2017 National Health Interview Survey (NHIS), a nationally representative survey of U.S. households conducted before the release of the new guidelines, Wee and colleagues characterized aspirin use for primary prevention of CVD.
The team found that about a quarter of adults aged 40 years or older without cardiovascular disease - approximately 29 million people - reported taking daily aspirin for prevention of heart disease. Of these, some 6.6 million people did so without a physician’s recommendation.
Peptic Ulcer Disease
The authors noted that a history of peptic ulcer disease - another contraindication for the routine use of aspirin - was not significantly associated with lower aspirin use as one would have expected.
“Our findings show a tremendous need for health care practitioners to ask their patients about ongoing aspirin use and to advise them about the importance of balancing the benefits and harms, especially among older adults and those with prior peptic ulcer disease,"
said lead author Colin O’Brien, MD, a senior internal medicine resident at BIDMC and fellow at Harvard Medical School.
“These findings are applicable to adults who do not have a history of cardiovascular disease or stroke. If you are currently taking aspirin, discuss it with your doctor to see if it is still needed for you,"
notes coauthor Stephen Juraschek, MD, PhD, a primary care physician at BIDMC.
Colin W. O’Brien, MD; Stephen P. Juraschek, MD, PhD; Christina C. Wee, MD, MPH Prevalence of Aspirin Use for Primary Prevention of Cardiovascular Disease in the United States: Results From the 2017 National Health Interview Survey Annals of Internal Medicine, 2019; DOI: 10.7326/M19-0953