The proportion of individuals aged over 65 on antidepressants has more than doubled in the past two decades, according to new research led by the University of East Anglia.
Despite a rise in antidepressant use, there was little change in the number of older people diagnosed with depression. The findings are based on the Cognitive Function and Ageing Studies, conducted at two time points - between 1991 and 1993, and between 2008 and 2011.
“Until now, little was known about how the relationship between the prevalence of depression and antidepressant use among older people has changed over time. The Cognitive Function and Ageing Studies led by the University of Cambridge have the ability to exam changes in the health needs of older people across generations based on random sampling and diagnostic methods held constant over time,“
said lead author Prof Antony Arthur, from UEA’s School of Health Sciences.
Researchers interviewed more than 15,000 over 65s in England and Wales to see whether the prevalence of depression and antidepressant use is changing.
“We asked participants about their health, daily activities, use of health and social care services, and the medications they were taking. We used a standardised interview process to ascertain the presence or absence of symptoms of depression and then applied diagnostic criteria to see whether the participant was considered to have ‘case level’ depression, a level of depression more severe than that characterised by minor mood symptoms, such as loss of energy, interest or enjoyment,“
The proportion of older people receiving anti-depressant medication more than doubled over two decades - from 4.2 per cent in the early nineties to 10.7 per cent 20 years later, according to the results. The estimated prevalence of depression among over 65s in the early 1990s was 7.9 per cent, compared to 6.8 per cent 20 years later.
In addition, depression and antidepressant use was more common in women than men at both time points. Depression was associated with living in a more deprived area.
The proportion of over 65s living in care homes declined, but prevalence of depression in care homes remained unchanged - affecting around one in ten residents. Across both time periods, most people with case-level depression were not on antidepressants, while most of those on antidepressants did not have depression.
“Between two comparable samples interviewed 20 years apart (1990-93 and 2008-11) we found little change in the prevalence of depression, but the proportion of participants taking antidepressants rose from 4 per cent to almost 11 per cent. This could be due to improved recognition and treatment of depression, overprescribing, or use of antidepressants for other conditions.
Whatever the explanation, substantial increases in prescribing has not reduced the prevalence of depression in the over-65 population. The causes of depression in older people, the factors that perpetuate it, and the best ways to manage it remain poorly understood and merit more attention,“
said Prof. Arthur.
 Antony Arthur, George M. Savva, Linda E. Barnes, Ayda Borjian-Boroojeny, Tom Dening, Carol Jagger, Fiona E. Matthews, Louise Robinson, Carol Brayne, and the Cognitive Function and Ageing Studies Collaboration. Changing prevalence and treatment of depression among older people over two decades. The British Journal of Psychiatry. DOI: https://doi.org/10.1192/bjp.2019.193