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Alcohol Triggers DNA Alterations That Increase Cravings

alcoholic

Binge and heavy drinking may trigger a long-lasting genetic change, resulting in an even greater craving for alcohol, according to a new study.

“We found that people who drink heavily may be changing their DNA in a way that makes them crave alcohol even more. This may help explain why alcoholism is such a powerful addiction, and may one day contribute to new ways to treat alcoholism or help prevent at-risk people from becoming addicted,”

says senior author Dipak K. Sarkar, a professor in and the director of the endocrine program in the animal sciences department at Rutgers University–New Brunswick.

In 2016, more than 3 million people died from the harmful use of alcohol, according a World Health Organization report. That’s 5 percent of all global deaths. More than three-quarters of alcohol-caused deaths were among men. The harmful use of alcohol also caused 5.1 percent of the worldwide toll of disease and injuries.

PER2 And POMC

Researchers focused on two genes implicated in the control of drinking behavior: PER2, which influences the body’s biological clock, and POMC, which regulates our stress-response system.

By comparing groups of moderate, binge, and heavy drinkers, the researchers found that an alcohol-influenced gene modification process called methylation changed the two genes in the binge and heavy drinkers. The binge and heavy drinkers also showed reductions in gene expression, or the rate at which these genes create proteins. These changes increased with greater alcohol intake.

Additionally, in an experiment, the drinkers viewed stress-related, neutral, or alcohol-related images. Researchers also showed them containers of beer and subsequently tasted beer, and their motivation to drink was evaluated.

The result: alcohol-fueled changes in the genes of binge and heavy drinkers were associated with a greater desire for alcohol.

The findings may eventually help researchers identify biomarkers — measurable indicators such as proteins or modified genes — that could predict an individual’s risk for binge or heavy drinking, says Sarkar.

Omkaram Gangisetty, Rajita Sinha, Dipak K. Sarkar
Hypermethylation of Proopiomelanocortin and Period 2 Genes in Blood Are Associated with Greater Subjective and Behavioral Motivation for Alcohol in Humans
Alcohol Clin Exp Re. doi:10.1111/acer.13932